COPD observations and studies
Data
supporting the assertion that smoking is not the only (maybe not even the
primary) cause of COPD comes from five separate categories of observations:
1. The demographic disparity between locales of
smoking prevalence and COPD death-rates, whether shown by comparisons of the
fifty states, the 805 Health Service Areas, or the county-by-county
examinations of a few states (two Colorado studies were briefly described
herein).
2. Examination of specific emphysema death records for
a decade in Colorado, which did not reveal significant correlation with
long-term smoking habits.
3. Anecdotal evidence from numerous hospice nurses
that they have attended many patients who died of COPD who had never smoked.
4. The uncommon (but not rare) genetic disorder Alpha-1
COPD has nothing to do with smoking – it affects an estimated 100,000 persons
in America, three times more than Cystic Fibrosis for example, and is virtually
untreatable. It is but one rare form of COPD, but one that makes a victim
'crazy' with the notion that 'most people who get COPD deserve it' as the New
York Times story about Johnny Carson's death phrased it.
Sally
Everett has written a book "Alpha 1
COPD, A Love Story" available at Amazon, and a blog about her
experiences and findings. See the chilling post
at http://curecopd.blogspot.com/2012/01/real-silent-killer.html.
5. Recent research into ultra-fine particle impacts,
to which we now turn:
COPD
ultra-fine particulate studies
Data supporting the sub-micron particulate
thesis as a possible causal agent for asthma has been mounting for two
decades. In 1993, scientists with
a National Institutes of Health grant released a study of the impact of small
particulate matter – in their case, particles smaller than 2.5 microns (known
as PM2.5) – in six “cities”, showing quite significant correlation
with COPD and asthmatic incidence. [1] The cities were, for the most part, small
rural towns, studied for a twenty year period, isolating the effect of air
pollution on control samples of both smokers and non-smokers. The conclusion was that there was fifty
percent higher correlation with small particulates (less than 2.5 microns) than
from smoking for COPD incidence.
In 1995, a longitudinal study of 552,138 individuals in 151 cities found that:
Particulate
air pollution was associated with cardiopulmonary and lung cancer mortality but
not with mortality due to other causes. Increased mortality is associated with
sulfate and fine particulate air pollution at levels commonly found in U.S.
cities. The increase in risk is not attributable to tobacco smoking, although
other unmeasured correlates of pollution cannot be excluded with certainty.[2]
A 2009 study by the same researchers correlates pollution and life expectancy:
We compiled data on
life expectancy, socioeconomic status, and demographic characteristics for 211
county units in the 51 U.S. metropolitan areas with matching data on
fine-particulate air pollution for the late 1970s and early 1980s and the late
1990s and early 2000s. Regression models were used to estimate the association
between reductions in pollution and changes in life expectancy, with adjustment
for changes in socioeconomic and demographic variables and in proxy indicators
for the prevalence of cigarette smoking.
A reduction in exposure to ambient fine-particulate air pollution contributed to significant and measurable improvements in life expectancy in the United States. [3]
Recent studies have taken this work deeper. Consider these 2013 findings at U C Davis:
Scientists
at the University of California, Davis, have, for the first time, developed a
system that can determine which types of air particles that pollute the
atmosphere are the most prevalent and toxic.
Previous
research has shown that air pollution containing fine and ultrafine particles
is associated with asthma, heart disease and premature death. This new study,
released today by the California Air Resources Board and the Electric Power
Research Institute, marks the first time that researchers have conducted source-oriented
sampling of these particles in the atmosphere.
For example, the researchers found that particulate emissions from vehicles, wood burning and residential cooking exhibited the most toxic effects at the study site in Fresno, which has among the nation’s highest rates of adult and childhood asthma.
“Right now, air quality standards are based on the mass of particulate matter and don’t distinguish between natural sources, like sea spray, and known toxic sources, like diesel exhaust,” said Anthony Wexler, the principal investigator and director of the Air Quality Research Center at UC Davis. “This study will help regulators control only the sources that are toxic, which saves money.”
The researchers used a single particle mass spectrometer, co-developed by Wexler, and 10 particle samplers to collect, analyze and separate ambient particles.
Laboratory mice then inhaled particle samples from the separate sources. Kent Pinkerton, a professor of pediatrics at the UC Davis School of Medicine, monitored their responses for signs of toxicity.
“This demonstrates that particles of different sources have different degrees and kinds of toxicity,” said Pinkerton. “We need to use this information to better understand the health effects of particulate matter. If we don’t, we’ll never really come up with a solution.” [4]
A 2009 study in New Orleans is
particularly intriguing for studying the early age impact:
Stephania Cormier, PhD, Associate Professor of
Pharmacology at LSU Health Sciences Center New Orleans, has shown for the first
time that early exposure to environmentally persistent free radicals (present
in airborne ultrafine particulate matter) affects long-term lung function. She
recently presented her latest research data at the 11th International Congress on
Combustion By-Products and Their Health Effects at the Environmental Protection
Agency Conference Center in Research Triangle Park, N.C.
Using protein profiling techniques, Dr. Cormier’s lab was able to determine that early exposure to these ultrafine pollutants caused genes to produce a number of proteins, including one associated with COPD and steroid-resistant asthma, and also caused proteins to misfold, rendering them dysfunctional. These genetic defects are linked to structural changes in the lung, airflow limitations, and permanent changes in immune responses.
“It is no surprise that elevations in airborne particulate matter (PM) are associated with increased hospital admissions for respiratory symptoms including asthma exacerbations,” notes Dr. Cormier.
“What has come as a surprise is that early exposure to elevated levels of PM elicits long-term effects on lung function and lung development in children.”
These results could be especially important because the US Environmental Protection Agency does not currently regulate ultrafine PM emissions.[5]
Others are now deciding to weigh in. Here’s an April 13, 2013 report from Rice University:
Rice University and the University of Houston will collaborate in a study to determine how
and where air quality in Houston affects the health of residents. Researchers will roam the streets in Houston
over the course of two years and use a mobile lab to collect data on air
pollutants smaller than 2.5 micrometers. Particles smaller than 10 micrometers
can get into the lungs and blood stream and affect a person's heart. In addition, researchers will determine which
neighborhoods in the city are at higher risk from those small particles, as a
result of traffic or industry…. The
study is funded by the Houston Endowment. [6]
The European Center for Energy, Environment, and Health (CEEH) produced a lengthy report in 2011, reviewing much pertinent literature, including Dockery and Pope papers, concluding that there is a clear connection between an increase in fine particulate matter (PM2.5) and the following four diseases: coronary heart disease (CHD), stroke, chronic obstructive pulmonary disease (COPD), and lung cancer [7]
SEEMS REMARKABLE WITH ALL OF THIS "EVIDENCE" that the AMA still resists believing that there is more to all of this than SMOKING
[1] Douglas Dockery, C. Arden Pope III, Xiping Xu, John D.
Spengler, James H. Ware, Martha E. Fay, Enjamin G. Ferris, Jr.; and Frank E.
Speizer, “An Association between Air Pollution and Mortality in Six U.S.
Cities,” New England Journal of Medicine (329: 24), December 9, 1993, pp. 1753-59
[2] Pope, CA, III; Thun, MJ; Namboodiri, MM; Dockery, DW;
Evans, JS; Speizer, FE; Heath, CW, Jr; : Particulate air pollution as a
predictor of mortality in a prospective study of US adults ,”
American Journal of Respiratory and Critical Care Medicine (3:1), pp.
669-674.
3] C. Arden Pope,
III, Ph.D., Majid Ezzati, Ph.D., and Douglas W. Dockery, Sc.D.; “Fine-Particulate
Air Pollution and Life Expectancy in the United States,” New England
Journal of Medicine, 2009; 360:376-386, January 22, 2009
[4] Ken Kerlin, “Scientists trace particulate air
pollution to its source.” UC
Davis News Service, February
19, 2013. The California Air
Resources Board and the Electric Power Research Institute (EPRI) funded the
study.
[5] “Infant Inhalation Of Ultrafine Air Pollution Linked To Adult Lung Disease,” Louisiana State University Health Sciences Center, July 23 2009; http://www.sciencedaily.com/releases/2009/07/090722123751.htm
[6] Bayan Raji, “Rice, UH to study how air pollution
impacts Houstonians,” Houston Business
Journal, April 24, 2013
[7] See CEEH Scientific Report 7a, “Description of the CEEH
health effects model – selection of concentration-response functions; “ http://www.ceeh.dk/CEEH_Reports/Report_7a/CEEH_Report_7a.pdf
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